Deletion of the Mitochondrial Flavoprotein Apoptosis Inducing Factor (AIF) Induces β-Cell Apoptosis and Impairs β-Cell Mass
نویسندگان
چکیده
منابع مشابه
Correction: Deletion of the Mitochondrial Flavoprotein Apoptosis Inducing Factor (AIF) Induces β-Cell Apoptosis and Impairs β-Cell Mass
BACKGROUND Apoptosis is a hallmark of beta-cell death in both type 1 and type 2 diabetes mellitus. Understanding how apoptosis contributes to beta-cell turnover may lead to strategies to prevent progression of diabetes. A key mediator of apoptosis, mitochondrial function, and cell survival is apoptosis inducing factor (AIF). In the present study, we investigated the role of AIF on beta-cell mas...
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in many models of programmed cell death, the mitochondrial protein aif translocates to the nucleus, where it induces the chromatin condensation and dna degradation. however, today it is well established that this flavoprotein is bifunctional. in addition to its lethal function in the nucleus of dying cells, aif plays a vital bioenergetic role in healthy ones by regulating mainly the activity of...
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In many models of programmed cell death, the mitochondrial protein AIF translocates to the nucleus, where it induces the chromatin condensation and DNA degradation. However, today it is well established that this flavoprotein is bifunctional. In addition to its lethal function in the nucleus of dying cells, AIF plays a vital bioenergetic role in healthy ones by regulating mainly the activity of...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2009
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0004394